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Myeloproliferative Disorders

New findings reported from University of Cambridge describe advances in myeloproliferative disorders

Published in Cancer Weekly, January 27th, 2009

"The myeloproliferative disorders are clonal disorders with frequent somatic gain-of-function alterations affecting tyrosine kinases. In these diseases, there is an increase in DNA damage and a risk of progression to acute leukemia," researchers in Cambridge, the United Kingdom report.

"The molecular mechanisms in myeloproliferative disorders that prevent apoptosis induced by damaged DNA are obscure. We searched for abnormalities of the proapoptotic Bcl-x(L) deamidation pathway in primary cells from patients with chronic myeloid leukemia (CML) or polycythemia vera, myeloproliferative disorders associated with the BCR-ABL fusion kinase and the Janus tyrosine kinase 2...

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