Cancer Weekly
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Apoptosis
Research in the area of apoptosis reported from W.X. Shu and colleagues
January 27th, 2009
"Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells, which was accompanied by typical apoptotic morphological changes and sharp decreased expression of Bcl-xL and Bcl-2," scientists in Wuhan, People's Republic of China report. "Furthermore, nucleophosmin, recently demonstrated to be mutated and aberrantly localized in the cytoplasm of leukaemia blasts in a high proportion of patients with acute myeloid...
Source: Cancer Weekly (2009-01-27)
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