Cancer Weekly
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Cancer Gene Therapy
Reports outline cancer gene therapy research from K.H. Jung and colleagues
January 27th, 2009
"Although the success of sodium/iodide symporter (NIS) gene-based cancer therapy is critically dependent on the level of radioiodide accumulation attained, recent evidence indicates that successful therapy relies not solely on NIS amount but also crucially on its functional activity. In this study, we investigated the role of kinase-linked signaling on the regulation of NIS function in cancer cells," scientists in Seoul, South Korea report. "T47D human breast cancer and PC-12 rat pheochromocytoma cells were transduced with the human NIS genes via an adenoviral vector. Cells were measured for I-125 uptake, and the effects of activation or inhibition of protein kinase C...
Source: Cancer Weekly (2009-01-27)
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