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Cancer Weekly

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Cancer Gene Therapy



Research on cancer gene therapy published by S.P. Ren et al



January 27th, 2009

According to a study from Beijing, People's Republic of China, "Incidence of nasopharyngeal carcinoma (NPC) remains high in endemic regions. Prevention of tumor recurrences and metastases is a crucial approach to improve therapeutic outcome in NPC patients."

"In this Study, we investigated the effects of the cotransfer of the tumor suppressor gene, p53, in combination with the immunostimulatory genes, GM-CSF and B7-1, on tumor regression and subsequent tumor recurrence. We constructed a recombinant adenovirus carrying human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes (Ad-p53/GM-CSF/B7-1 ), which mediated high-level expression...


Source: Cancer Weekly (2009-01-27)

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