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Gene Therapy
Study data from Kaohsiung Medical University update understanding of gene therapy
February 3rd, 2009
According to a study from Kaohsiung, Taiwan, "Non-invasive gene monitoring is important for most gene therapy applications to ensure selective gene transfer to specific cells or tissues. We developed a non-invasive imaging system to assess the location and persistence of gene expression by anchoring an anti-dansyl (DNS) single-chain antibody (DNS receptor) on the cell surface to trap DNS-derivatized imaging probes." "DNS hapten was covalently attached to cross-linked iron oxide (CLIO) to form a 39 +/- 0.5nm DNS-CLIO nanoparticle imaging probe. DNS-CLIO specifically bound to DNS receptors but not to a control single-chain antibody receptor. DNS-CLIO (100 mc M Fe) was...
Source: Cancer Weekly (2009-02-03)
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