Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Necrosis
Studies from University of California update current data on necrosis
February 3rd, 2009
"Tumor necrosis factor (TNF)-alpha is a type-II transmembrane protein that is cleaved by TNF-alpha-converting enzyme (TACE/ADAM-17) to release soluble TNF, a cytokine with potent antitumor properties whose use in clinical applications is limited by its severe systemic toxicity. We found that human cells transfected with vectors encoding TNF without the TACE cleavage site (Delta TACE-TNF) still released functional cytokine at substantial levels that varied between transfected cell lines of different tissue types," scientists writing in the journal Cancer Gene Therapy report. "Vectors encoding membrane-associated domains of CD154, another TNF-family protein,...
Source: Cancer Weekly (2009-02-03)
|
