Cancer Weekly
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Acute Myeloid Leukemia
Research reports on acute myeloid leukemia from M.E.D. Chamuleau and colleagues provide new insights
February 3rd, 2009
"Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression," researchers in Netherlands report. "Recently, blasts of patients with acute myeloid leukemia were shown to express indoleamine 2,3-dioxygenase. We determined INDO (encoding gene for indoleamine 2,3-dioxygenase) mRNA expression in leukemic blasts of 286 patients with acute myeloid leukemia by gene-expression profiling. Results were validated by quantitative polymerase chain reaction analysis in blasts of an independent cohort...
Source: Cancer Weekly (2009-02-03)
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