Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy research has been reported by scientists at Nanjing Medical University
February 3rd, 2009
"Gemcitabine is the first-line chemotherapeutic agent for advanced adenocarcinoma of the pancreas; however, chemoresistance to gemcitabine remains a major cause of failure for the clinical treatment of this disease. Polo-like kinase 1 (Plk-1) is highly expressed in pancreatic cancer cell lines and pancreatic tumour tissues, and is involved in a wide variety of cell cycle processes," scientists in Nanjing, People's Republic of China report. "Nevertheless, its biological role and implication for gemcitabine resistance are not clearly defined. In this study, we used RNA-interference (RNAi)-mediated depletion of Plk-1 to determine its potential for sensitizing pancreatic...
Source: Cancer Weekly (2009-02-03)
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