Cancer Weekly
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Angiogenesis
Investigators at Washington University zero in on angiogenesis
February 3rd, 2009
According to recent research published in the Faseb Journal, "Our objectives were 1) to characterize angiogenesis in the MDA-MB-435 xenograft mouse model with three-dimensional (3D) MR molecular imaging using alpha(5)beta(1)(RGD)- or irrelevant RGS-targeted paramagnetic nanoparticles and 2) to use MR molecular imaging to assess the antiangiogenic effectiveness of alpha(5)beta(1)(alpha(v)beta(3))- vs. alpha(v)beta(3)-targeted fumagillin (50 mu g/kg) nanoparticles. Tumor-bearing mice were imaged with MR before and after administration of either alpha(5)beta(1)(RGD) or irrelevant RGS-paramagnetic nanoparticles." "In experiment 2, mice received saline or...
Source: Cancer Weekly (2009-02-03)
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