Cancer Weekly
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Angiogenesis
Research from S.C. Chen and colleagues provide new insights into angiogenesis
February 3rd, 2009
According to a study from the United States, "The potent effects of PAI-1 on tumorigenesis and angiogenesis in various experimental models are complex, complicated and at times contradictory. We determined the therapeutic potential of PAI-1 for inhibiting bladder tumor invasion under conditions that closely mimic the clinical setting." "An orthotopic rat bladder tumor model was established by implanting AY-27 rat transitional carcinoma cells into the bladder lumen of syngeneic Fischer F344 rats. Three weeks after implantation I AM PAI-1 was administrated directly into the bladder lumen twice weekly for 2 weeks. Two days after the final treatment tumor size, total...
Source: Cancer Weekly (2009-02-03)
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