Cancer Weekly
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Angiogenesis
Studies from Hokkaido Health Science University provide new data on angiogenesis
February 3rd, 2009
According to a study from Ishikari, Japan, "The expression of thymidine phosphorylase (TP) is strongly associated with angiogenesis in tumors and activation of antitumor agents. We designed a novel 5-I-125-labeled 6-(2-iminoimidazolidinyl)methyluracil hydrochloride ([I-125]516IMUHCl) to develop an effective radiotracer for in vivo assessment of TIP expression in tumors and prognosis of cancer chemotherapy." "Radiotracer synthesis was achieved by radioiodination of the precursor, 6-(2-iminoimidazolidinyl)methyluracil at the C-5 position with NCS/radioiodide. After purification by HPLC, [I-125]56IMU-HCl was obtained in high radiochemical yield with satisfactory specific...
Source: Cancer Weekly (2009-02-03)
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