Cancer Weekly
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Atherosclerosis
Findings in atherosclerosis reported from Vanderbilt University, Medical Department
February 3rd, 2009
According to recent research published in the journal Cell Metabolism, "Prostaglandin (PG) E-2, a major product of activated macrophages, has been implicated in atherosclerosis and plaque rupture. The PGE(2) receptors, EP2 and EP4, are expressed in atherosclerotic lesions and are known to inhibit apoptosis in cancer cells." "To examine the roles of macrophage EN and EP2 in apoptosis and early atherosclerosis, fetal liver cell transplantation was used to generate LDLR-/- mice chimeric for EP2(-/-) or EP4(-/-) hematopoietic cells. After 8 weeks on a Western diet, EP4-/-, LDLR-/- mice, but not EP2(-/-) -> LDLR-/- mice, had significantly reduced aortic...
Source: Cancer Weekly (2009-02-03)
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