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Autoimmune Exocrinopathy
New autoimmune exocrinopathy findings from University of Tokushima described
February 3rd, 2009
According to recent research published in the Journal of Experimental Medicine, "Although several autoimmune diseases are known to develop in postmenopausal women, the mechanisms by which estrogen deficiency influences autoimmunity remain unclear. Recently, we found that retinoblastoma-associated protein 48 (RbAp48) induces tissue-specific apoptosis in the exocrine glands depending on the level of estrogen deficiency." "In this study, we report that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjogren's syndrome. CD4(+) T cell-mediated autoimmune lesions were aggravated with age, in association with...
Source: Cancer Weekly (2009-02-03)
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