Cancer Weekly
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Cancer Gene Therapy
Reports summarize cancer gene therapy study results from Xuzhou Medical College, Medical College
February 3rd, 2009
"RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown purpose and holds great promise for the treatment of cancer. Our previous study demonstrated that the reduction of Ki-67 expression by means of chemically synthesized siRNAs and shRNAs expressed from plasmid resulted in proliferation inhibition in human renal carcinoma cells," scientists in Xuzhou, People's Republic of China report. "In this study, we constructed a novel oncolytic adenovirus-based shRNA expression system, ZD55-Ki67, and explored ZD55-Ki67-mediated RNAi for Ki-67 gene silencing. Our results showed that ZD55-Ki67 could induce silencing of the Ki- 67 gene effectively, allow...
Source: Cancer Weekly (2009-02-03)
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