Cancer Weekly
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Gene Therapy
Research results from University of Modena update knowledge of gene therapy
February 10th, 2009
"Deficiency of the basement membrane component laminin-5 (LAM5) causes junctional epidermolysis bullosa (JEB), a severe and often fatal skin adhesion defect. Autologous transplantation of epidermal stem cells genetically corrected with a Moloney leukemia virus (MLV)-derived retroviral vector reconstitutes LAM5 synthesis, and corrects the adhesion defect in JEB patients," researchers in Modena, Italy report. "However, MLV-derived vectors have genotoxic characteristics, and are unable to reproduce the physiological, basal layer -restricted expression of LAM5 chains. We have developed an alternative gene transfer strategy based on self-inactivating (SIN) or long terminal...
Source: Cancer Weekly (2009-02-10)
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