Cancer
Research from Ohio University has provided new information about cancer
Published in Cancer Weekly, February 10th, 2009
"DNA is believed to be the molecular target for the cytotoxic activities of platinum (Pt) anticancer drugs. We report here a class of platinum(II)- and platinum(IV)-pyrophosphato complexes that exhibit cytotoxicity comparable with and, in some cases, better than cisplatin in ovarian cell lines (A2780, A2780/C30, and CHO), yet they do not show any evidence of covalent binding to DNA," scientists in the United States report.
"Moreover, some of these compounds are quite effective in cisplatin- and carboplatin-resistant cell line A2780/C30. The lack of DNA binding was demonstrated by the absence of a detectable Fit signal by atomic absorption spectroscopy using isolated DNA...
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Source: Cancer Weekly (2009-02-10)
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