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Cancer Gene Therapy
Research results from University of Wisconsin, Medical Science Center update understanding of cancer gene therapy
February 10th, 2009
A report, 'Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator,' is newly published data in Clinical Cancer Research. According to recent research published in the journal Clinical Cancer Research, "Notch, a type 1 transmembrane protein, plays a key role in the development of many tissues and organ types. Aberrant Notch signaling, found in a wide variety of human cancers, contributes to tumor development." "Because Notch1 was found to be overexpressed in prostate cancer (PCa) cells and human PCa tissue, we therefore tested our hypothesis...
Source: Cancer Weekly (2009-02-10)
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