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Cancer Gene Therapy
Researchers from Medical University of South Carolina describe findings in cancer gene therapy
February 10th, 2009
Investigators publish new data in the report '10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status.' According to recent research published in the journal Molecular Cancer Research, "10-Formyltetrahydrofolate dehydrogenase (FDH) suppresses cancer cell proliferation through p53-dependent apoptosis but also induces strong cytotoxicity in p53-deficient prostate cells. In the present study, we have shown that FDH induces apoptosis in PC-3 prostate cells through simultaneous activation of the c-Jun-NH(2)-kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways with JNK...
Source: Cancer Weekly (2009-02-10)
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