Glioblastoma
Data on glioblastoma detailed by researchers at Wake Forest University, Brain Tumor Center
Published in Cancer Weekly, February 10th, 2009
"The ephrinA1 ligand exerts antioncogenic effects in tumor cells through activation and downregulation of the EphA2 receptor and has been described as a membrane-anchored protein requiring clustering for function. However, while investigating the ephrinA1/EphA2 system in the pathobiology of glioblastoma multiforme (GBM), we uncovered that ephrinA1 is released from GBM and breast adenocarcinoma cells as a soluble, monomeric protein and is a functional form of the ligand in this state," scientists in the United States report.
"Conditioned media containing a soluble monomer of ephrinA1 caused EphA2 internalization and downregulation, dramatic alteration of cell morphology...
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Source: Cancer Weekly (2009-02-10)
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