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Leukemia Gene Therapy
New leukemia gene therapy study findings recently were published by researchers at Cornell University
February 10th, 2009
A report, 'Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling,' is newly published data in European Journal of Cell Biology. "1,25-dihydroxyvitamin D3 (vitamin D3) induces differentiation of HL-60 human myeloid leukemia cells; however, the signaling mechanism governing these effects is not fully clear. Here, we show that vitamin D3 induced functional differentiation by Akt through Raf/MEK/ERK MAPK signaling," researchers in the United States report. "Vitamin D3 downregulated Akt, weakened Akt-Raf1 interaction, and subsequently activated the Raf/MEK/ERK MAPK pathway. Pharmacological inhibition of MEK/ERK...
Source: Cancer Weekly (2009-02-10)
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