Glioma
Research from K. Farber and co-researchers yields new findings on glioma
Published in Cancer Weekly, February 10th, 2009
"Integrins are heterodimeric transmembrane proteins, which mediate cell-cell and cell-extracellular matrix (ECM) interaction. We show, that an inhibitor of alpha5 beta1 integrin (alpha 5 beta 1).JSM6427, attenuated glioma growth and decreased the density of microglia at the tumor border. 21 days after glioma cell injection into an experimental mouse model, the tumor volume was significantly smaller after treating animals for 14 days with JSM6427 as compared to controls," scientists writing in the journal Molecular and Cellular Neuroscience report.
"We could demonstrate the expression of integrin alpha 5 beta 1 on both microglia and glioma cell using flow...
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Source: Cancer Weekly (2009-02-10)
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