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Researchers from Charite University report recent findings in life sciences

Published in Cancer Weekly, February 10th, 2009

"The transcription factor hypoxia-inducible factor 1 (HIF-1) alpha is abundantly expressed in the majority of human carcinomas and their metastases. HIF-1 alpha controls central metastasis-associated pathways such as glycolysis, angiogenesis, and invasion," scientists writing in the journal Cancer Research report.

"Functional inhibition of HIF-1 alpha. leads to impaired metastasis formation in murine tumor models. However, the precise molecular mechanisms underlying the metastasis-promoting role of HIF-1 alpha have not been fully characterized. The ability of transformed epithelial cells to initiate the metastatic cascade relies on their ability to escape...

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