Myeloma
Studies from Y.J. Shi et al further understanding of myeloma
Published in Cancer Weekly, February 10th, 2009
"IL-6 increased c-myc translation, which was resistant to rapamycin, indicating a mechanism independent of mammalian target of rapamycin (mTOR) and cap-dependent translation. In contrast, the cytokine enhanced cap-independent translation via a stimulatory effect on the myc internal ribosome entry site (IRES). As known IRES-trans-activating factors (ITAF) were unaffected by IL-6,...
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Source: Cancer Weekly (2009-02-10)
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