Alcoholism

Researchers at University of Udine publish new data on alcoholism

Published in Cancer Weekly, February 10th, 2009

According to a study from Udine, Italy, "A single nucleotide polymorphism (SNP) C677T in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified. The TT or CT genotypes show a marked reduction of the enzyme activity; this causes higher homocysteine levels and alterations of folate metabolism."

"Folate metabolism is essential for DNA synthesis and methylation, crucial steps in carcinogenesis. In this paper, we investigated whether the MTHFR C677T SNP could influence the occurrence of hepatocellular carcinoma (HCC) in a cohort of patients transplanted for end stage liver disease of different etiologies. Two hundred and twelve consecutive patients who...

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Source: Cancer Weekly (2009-02-10)

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