Ovarian Cancer

Studies from College of Medicine reveal new findings on ovarian cancer

Published in Cancer Weekly, February 10th, 2009

According to a study from the United States, "The pathophysiological mechanisms that drive the development and progression of epithelial ovarian cancer remain obscure. Recently, we identified TCEAL7 as a transcriptional regulatory protein often downregulated in epithelial ovarian cancer."

"However, the biological significance of such downregulation in cancer is not currently known. Here, we show that TCEAL7 is downregulated frequently in many human cancers and that in immortalized human ovarian epithelial cells this event promotes anchorage-independent cell growth. Mechanistic investigations revealed that TCEAL7 associates with cyclin D1 promoter containing Myc E-box...

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Source: Cancer Weekly (2009-02-10)

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