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Alzheimer Disease
Researchers from Queen's University detail new studies and findings in the area of Alzheimer disease
February 10th, 2009
"Research into the cause of Alzheimer's disease (AD) has identified strong connections to cholesterol. Cholesterol and cholesterol esters can modulate amyloid precursor protein (APP) processing, thus altering production of the A beta peptides that deposit in cortical amyloid plaques," scientists in North Ireland report. "Processing depends on the encounter between APP and cellular secretases, and is thus subject to the influence of cholesterol-dependent factors including protein trafficking, and distribution between membrane subdomains. We have directly investigated endogenous membrane beta-secretase activity in the presence of a range of membrane cholesterol levels in...
Source: Cancer Weekly (2009-02-10)
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