Cancer Weekly
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Angiogenesis
Findings from Vanderbilt University in angiogenesis reported
February 10th, 2009
"The transcription factor nuclear factor-kappa B (NF-kappa B) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappa B activator, I kappa B kinase-alpha (IKK alpha), but not IKK beta, promotes endothelial cell motility and tumor angiogenesis," scientists in the United States report. "IKK alpha is elevated in tumor vasculature compared with normal endothelium. Overexpression of IKK alpha in endothelial cells promoted cell motility and vascular tubule formation in a three-dimensional culture assay, and conversely, knockdown of IKK...
Source: Cancer Weekly (2009-02-10)
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