Cancer Weekly
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Cancer Gene Therapy
Reports from Mayo Clinic add new data to research in cancer gene therapy
February 10th, 2009
According to recent research from the United States, "Our objectives were to, first, determine the oncolytic potential of an engineered measles virus expressing the sodium-iodide symporter gene (MV-NIS) for intratumoral (IT) therapy of pancreatic cancer and, second, evaluate NIS as a reporter gene for in vivo monitoring and quantitation of MV-NIS delivery, viral spread, and gene expression in this tumor model. Cultured human pancreatic cancer cells were infected with MV-NIS." "Light microscopy, cell viability, and iodide uptake assays were used to confirm viral infection and NIS gene expression and function in vitro. Human pancreatic tumor xenografts were established in...
Source: Cancer Weekly (2009-02-10)
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