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Apoptosis
Data on apoptosis discussed by researchers at University of Kalyani
February 10th, 2009
According to a study from Kalyani, India, "To investigate the role of poly(ADP-ribose) polymerase (PARP) in the physiological condition of cell growth, we studied the ability of PARP inhibitors to induce apoptosis. Benzamide (BA) and 4-amino-1,8-naphthalimide (NAP), two well-known inhibitors of PARP, treatment increased nuclear fragmentation and caspase-3 activity in HeLa (Human cervical cancer cell line) cells." "The increase of cellular NAD(+) level was observed in HeLa cells treated with BA in comparison with untreated control cells. For unrevealing the specific PARP family member responsible for such induction of apoptosis we knocked down and over-expressed PARP-1...
Source: Cancer Weekly (2009-02-10)
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