Cancer Weekly
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Apoptosis
Studies from T. Skoog and co-researchers yield new data on apoptosis
February 10th, 2009
According to a study from Huddinge, Sweden, "In the skin, expression of several matrix metalloproteinases (MMPs) occurs in response to tissue injury, tumorigenesis, angiogenesis, apoptosis, and inflammation. The recently cloned MMP-21 has been implicated in skin development and various epithelial cancers." "In this study, we found that it is also expressed by differentiated keratinocytes (KCs) in various benign skin disorders, in which it was not associated with KC apoptosis or proliferation, and in organotypic cultures. Furthermore, MMP-21 was induced in keratinocytes in association with increased calcium and presence of the differentiation marker filaggrin. In stably...
Source: Cancer Weekly (2009-02-10)
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