Ovarian Cancer Therapy
Scientists at University of California, Moores Cancer Center describe research in ovarian cancer therapy
Published in Cancer Weekly, February 10th, 2009
Investigators publish new data in the report 'Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1.' "The copper transporter 1 (CTR1) is a major influx transporter for platinum drugs. However, the accumulation of cisplatin in human ovarian carcinoma cells is limited by the fact that cisplatin triggers the down-regulation and proteasomal degradation of CTR1, thereby limiting its own uptake," scientists writing in the journal Clinical Cancer Research report.
"We sought to determine whether proteasome inhibition using bortezomib would prevent human CTR1 (hCTR1) degradation and...
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Source: Cancer Weekly (2009-02-10)
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