Breast Cancer

Reports from K.J. Mcinnes et al highlight recent research in breast cancer

Published in Cancer Weekly, February 10th, 2009

According to a study from Clayton, Australia, "Aromatase is a member of the cytochrome P450 superfamily of enzymes which catalyses the rate-limiting step in the biosynthesis of estrogens. A number of clinical studies have highlighted the importance of local estrogen production in adipose tissue."

"In particular, in the postmenopausal woman, the degree of her estrogenization is mainly determined by the extent of her adiposity and it is this extragonadal source of estrogen that likely contributes to breast cancer development and progression. The mechanisms regulating aromatase expression in adipose tissue however, have not been fully elucidated. In this study, we have...

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Source: Cancer Weekly (2009-02-10)

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