Breast Cancer

Studies from University of Hong Kong provide new data on breast cancer

Published in Cancer Weekly, February 17th, 2009

"The BRCA1 gene is an important breast-cancer susceptibility gene. Promoter polymorphisms can alter the binding affinity of transcription factors, changing transcriptional activity and may affect susceptibility to disease," researchers in Hong Kong, People's Republic of China report.

"Using direct sequencing of the BRCA1 promoter region, we identified four polymorphisms c.-2804T -> C (rs799908:T -> C), c.-2265C -> T (rs11655505:C -> T), c.-2004A -> G (rs799906:A -> G) and c.-1896(ACA)(1)- >(ACA)(2) (rs8176071:(ACA)(1)- >(ACA)(2)) present in Hong Kong Chinese. Each polymorphism was studied independently and in combination by functional assays....

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Source: Cancer Weekly (2009-02-17)

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