Cancer Weekly
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Cancer Gene Therapy
Research from Boston University, Cancer Research Center broadens understanding of cancer gene therapy
February 17th, 2009
Data detailed in 'Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control' have been presented. "HIC1 is a newly discovered tumor suppressor and transcriptional repressor that is frequently silenced in human tumors. HIC1 protein expression has been linked to better outcomes in breast cancers," scientists in the United States report. "The molecular mechanism underlying HIC1-mediated transcriptional and growth suppression, and the relevant targets of HIC1-mediated transcriptional modulation, is currently unclear. We have identified an HIC1 DNA-binding site in E2F-responsive gene promoters and...
Source: Cancer Weekly (2009-02-17)
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