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Cancer Gene Therapy
Research on cancer gene therapy detailed by scientists at Case Western Reserve University, CASE Comprehensive Cancer Center
February 17th, 2009
Data detailed in 'Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity' have been presented. "Targeted therapy against epidermal growth factor receptor (EGFR) represents a major therapeutic advance in lung cancer treatment. Somatic mutations of the EGFR gene, most commonly L858R (exon 21) and short in-frame exon 19 deletions, have been found to confer enhanced sensitivity toward the inhibitors gefitinib and erlotinib," scientists in the United States report. "We have recently identified an EGFR mutation E884K, in combination with L858R, in a patient with advanced lung cancer who progressed on...
Source: Cancer Weekly (2009-02-17)
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