Environmental Health
Study data from National Institute of Environmental Health Sciences provide new insights into environmental health
Published in Cancer Weekly, February 17th, 2009
According to recent research from the United States, "A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1 I mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program, 2006]. The incidence of alveolar/bronchiolar adenomas and carcinomas in the 200 and 300 mg/kg groups was significantly higher (P = 0.027 and 0.007, respectively) in male offspring, but not in females (P = 0.338 and 0.315, respectively)."
"The purpose of the present study was to evaluate K-ras mutation status in lung tumors from the female offspring in AZT exposed...
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Source: Cancer Weekly (2009-02-17)
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