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Cancer Gene Therapy
University of Virginia reports research in cancer gene therapy
February 17th, 2009
A report, 'Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions,' is newly published data in Oncogene. "The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) and several transcriptional regulators," researchers in the United States report. "We investigated the relationship between cellular BRCA1 levels and tamoxifen sensitivity....
Source: Cancer Weekly (2009-02-17)
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