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Lymphoma Gene Therapy
Researchers at University Kebangsaan Malaysia, Pathology Department target lymphoma gene therapy
February 17th, 2009
Investigators publish new data in the report 'BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.' According to a study from Kuala Lumpur, Malaysia, "The t(14;18)(q32;q21) chromosomal translocation induces BCL2 protein overexpression in most follicular lymphomas. However the expression of BCL2 is not always homogeneous and may demonstrate a variable degree of heterogeneity." "This study analysed BCL2 protein expression pattern in 33 cases of t(14;18)-positive follicular lymphomas using antibodies against two different epitopes (i.e. the widely used antibody BCL2/124 and an alternative antibody E17). 16/33 (49%) cases demonstrated...
Source: Cancer Weekly (2009-02-17)
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