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Acute Lymphoblastic Leukemia
Scientists at University of Newcastle discuss research in acute lymphoblastic leukemia
February 17th, 2009
"Inactivation of the tumor suppressor gene, CDKN2A, can occur by deletion, methylation, or mutation. We assessed the principal mode of inactivation in childhood acute lymphoblastic leukemia ( ALL) and frequency in biologically relevant subgroups," scientists in the United Kingdom report. "Mutation or methylation was rare, whereas genomic deletion occurred in 21% of B-cell precursor ALL and 50% of T-ALL patients. Single nucleotide polymorphism arrays revealed copy number neutral (CNN) loss of heterozygosity (LOH) in 8% of patients. Array-based comparative genomic hybridization demonstrated that the mean size of deletions was 14.8 Mb and biallelic deletions composed a...
Source: Cancer Weekly (2009-02-17)
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