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Cancer Weekly

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Bioengineering



Findings in bioengineering reported from A. Ambade and co-researchers



February 17th, 2009

"The potential of cytokine gene therapy using naked plasmid DNA encoding human IL-2 cDNA in a xenograft nude mouse model was investigated. To overcome the T cell deficiency in nude mice, Adoptive T Cell Transfer [ATCT] into tumour bearing nude mice was performed," scientists in India report.

"The migration of T cells was tracked in vivo using USE labeling. IL-2 in circulation was observed till day 15 with the levels reaching a peak by day 3. Significant activation of transferred T cells (CD69(+), CD25(+)) as well as significant increase in levels of NK cells (CD49b(+)) was seen in animals receiving IL-2," wrote A. Ambade and colleagues.

The...


Source: Cancer Weekly (2009-02-17)

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