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Non-Small Cell Lung Cancer

Study data from E.H. Lim and co-authors update knowledge of non-small cell lung cancer

Published in Cancer Weekly, February 17th, 2009

According to recent research from Singapore, Singapore, "Progression of non-small cell lung cancer (NSCLC) from early- to late-stage may signify the accumulation of gene mutations. An advanced-stage tumor's mutation profile may also have prognostic value, guiding treatment decisions."

"Mutation detection of multiple genes is limited by the low amount of deoxyribonucleic acid extracted from low-volume diagnostic lung biopsies. We explored whole genome amplification (WGA) to enable multiple molecular analyses. Eighty-eight advanced-stage NSCLC patients were enrolled. Their low-volume lung biopsies underwent WGA before direct sequencing for epidermal growth factor receptor...

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