Cancer Weekly
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Cancer Gene Therapy
Findings in cancer gene therapy reported from M. Takanashi and co-researchers
February 17th, 2009
According to a study from Shinjuku, Japan, "Heterochromatin protein 1 (HP1) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (alpha, beta, and gamma) occur in mammals, but their functional differences are still incompletely understood. in this study, we found that HP1 gamma levels are decreased during adipocyte differentiation, whereas HP1 alpha and 13 levels are expressed constitutively during adipogenesis in cultured preadipocyte cells." "In addition, ectopic overexpression of HP1 gamma inhibited adipogenesis. Furthermore, we did not detect any HP1 gamma protein in the differentiated cells of various normal...
Source: Cancer Weekly (2009-02-17)
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