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Antisense Technology
Studies from U. Orfanelli et al further understanding of antisense technology
February 17th, 2009
"It has been proposed that in cancer, where the bulk of the genome becomes hypomethylated, there is an increase in transcriptional noise that might lead to the generation of antisense transcripts that could affect the function of key oncosuppressor genes, ultimately leading to malignant transformation. Here, we describe the computational identification of a melanoma-enriched antisense transcript, TRPM2-AS, mapped within the locus of TRPM2, an ion channel capable of mediating susceptibility to cell death," scientists writing in the journal Cell Research report. "Analysis of the TRPM2-AS genomic region indicated the presence in the same region of another...
Source: Cancer Weekly (2009-02-17)
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