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Apoptosis
Findings from National Cheng-Kung University, Medical Department in apoptosis reported
February 17th, 2009
"Bufotalin is one of the bufadienolides isolated from Formosan Ch'an Su, which is made of the skin and parotid glands of toads. Ingestion of toad venom results in severe morbidity and high mortality," scientists writing in the Journal of Agricultural and Food Chemistry report. "Although Ch'an Su is clinically toxic, it has been used as an important traditional Chinese medicine for heart failure and pains. In this study, bufotalin-induced apoptosis in human hepatocellular carcinoma Hep 3B cells was investigated. The results indicate that externalization of phosphaticlylserine, accumulation of sub-G, cells, fragmentation of DNA, and formation of apoptotic bodies...
Source: Cancer Weekly (2009-02-17)
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