Cancer Weekly
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Apoptosis
Reports outline apoptosis study results from H. He et al
February 17th, 2009
"The Protection of telomeres 1 (POT1) protein is a single-stranded telomere binding protein that is essential for proper maintenance of telomere length. Disruption of POT1 function leads to chromosome instability and loss of cellular viability," scientists in the United States report. "Here, we show that targeted deletion of the mouse Pot1b gene results in increased apoptosis in highly proliferative tissues. In the setting of telomerase haploinsufficiency, loss of Pot1b results in depletion of germ cells and complete bone marrow failure due to increased apoptosis, culminating in premature death. Pot1b(-/-) mTR(-/-) hematopoietic progenitor and stem cells display...
Source: Cancer Weekly (2009-02-17)
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