Cancer Weekly
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Apoptosis
Studies conducted at S.F. Scrace et al on apoptosis recently published
February 17th, 2009
"Transient treatment with small molecule CDK inhibitors is toxic to cancer cells and leads to depletion of anti-apoptotic proteins and Chk1, coupled with DNA damage and induction of apoptosis. Here we have examined, which of these phenomena are necessary for CDK inhibitors to have an anti-proliferative effect," scientists in Cambridge, the United Kingdom report. "We find that 24 hours treatment with either a primarily CDK2-specific, or a primarily CDK7/9-specific, antagonist eliminates proliferative potential even if apoptosis is blocked and the tendency of CDK inhibition to result in DNA damage is overcome by expression of recombinant Chk1. Loss of proliferative...
Source: Cancer Weekly (2009-02-17)
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