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Cancer Gene Therapy
New cancer gene therapy research from Fourth Military Medical University described
February 17th, 2009
"To investigate the inhibiting mechanism of multi-drug resistance (MDR) using expression vectors of short hairpin RNA (shRNA) in a MDR human ovarian cancer cell line (A2780/cp70). Two shRNA expression vectors were constructed and introduced into A2780/cp70 cells," scientists in Xian, People's Republic of China report. "Expression of MRP2 mRNA was assessed by RT-PCR, and Mrp2 expression was determined by Western blot and immunocytochemistry. Apoptosis and sensitization of the cells to cisplatinum were quantified by flow cytometry and methyl-thiazol-tetrazolium (MTT) assays. Cellular cisplatinum accumulation was assayed by laser scanning confocal microscopy (LSCM). In...
Source: Cancer Weekly (2009-02-17)
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