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Cancer Gene Therapy
Scientists at INSERM target cancer gene therapy
February 24th, 2009
A report, 'Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells,' is newly published data in Carcinogenesis. According to recent research from Lyon, France, "Human telomerase reverse transcriptase (hTERT) is expressed in most cancer cells. Paradoxically, its promoter is embedded in a hypermethylated CpG island." "A short region escapes to this alteration, allowing a basal level of transcription. However, the methylation of adjacent regions may play a role in the maintenance of low hTERT expression. It is now well established that methyl-CpG...
Source: Cancer Weekly (2009-02-24)
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