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Cancer Gene Therapy
Studies from Seoul National University, Dental Research Institute yield new data on cancer gene therapy
February 24th, 2009
Fresh data on cancer gene therapy are presented in the report 'CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells.' "Oral squamous cell carcinomas (OSCCs) are characterized by a high degree of local invasion and a high rate of metastases to cervical lymph nodes. Downregulation of CXCR-4 by siRNA inhibits invasion and growth of breast and colon cancer cells," scientists in Seoul, Korea report. "However, there have been no reports on the downregulation of CXCR-4 by small interfering RNA (siRNA) in oral cancer cells. We generated two stable CXCR-4-knockdown clones (KBsi and KOSCC-25Bsi) from the KB and...
Source: Cancer Weekly (2009-02-24)
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