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Leukemia Gene Therapy
Scientists at University of Pennsylvania, Department of Medicine describe research in leukemia gene therapy
February 24th, 2009
New research, 'BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold,' is the subject of a report. "Earlier reports have suggested that the BCR/ABL oncogene, associated with chronic myeloid leukemia, induces a mutator phenotype; however, it is unclear whether this leads to long-term changes in chromosomes and whether the phenotype is found in primary chronic myelogeneous leukemia (CML) cells. We have addressed both these issues," investigators in the United States report. "BCR/ABL-expressing cell lines show an increase in DNA breaks after treatment with etoposide as compared to control cells. However, although...
Source: Cancer Weekly (2009-02-24)
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